HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3
نویسندگان
چکیده
منابع مشابه
Matrin 3 Binds and Stabilizes mRNA
Matrin 3 (MATR3) is a highly conserved, inner nuclear matrix protein with two zinc finger domains and two RNA recognition motifs (RRM), whose function is largely unknown. Recently we found MATR3 to be phosphorylated by the protein kinase ATM, which activates the cellular response to double strand breaks in the DNA. Here, we show that MATR3 interacts in an RNA-dependent manner with several prote...
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Recent advances have led to a new understanding of how mRNAs are exported from the nucleus to the cytoplasm. This process requires a heterodimeric mRNA export receptor that is part of an elaborate machinery conserved from yeast to humans. Export of mRNAs is coupled to upstream steps in gene expression, such as pre-mRNA splicing, and to downstream events, including nonsense-mediated decay.
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ژورنال
عنوان ژورنال: Virology
سال: 2013
ISSN: 0042-6822
DOI: 10.1016/j.virol.2012.10.032